SYT 18q11.2 Synovial Sarcoma*
Expected Turnaround Time
9 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.
Clinical Information
FISH test for Synovial sarcomas, which account for 5-10% of soft tissue sarcomas, are seen mainly in adolescents and adults aged between 15 and 45 years. More than 85-95% of them arise in the deep soft tissues of the extremities. Synovial sarcomas harbor the t(X;18) translocation. *Testing performed by affiliate laboratory.
Specimen Requirements
Specimen Requirements
- Whole Blood: 5 mL, EDTA preferred (NaHep accepted)
- Bone Marrow Aspirate: 3 mL, EDTA preferred (NaHep accepted)
Specimen Stability
72 hours
Storage Requirements
- Whole Blood: 2°C to 25°C
- Bone Marrow Aspirate: 2°C to 25°C
- Fixed Cytogenetically Prepared Cells: -28°C to -15°C
Shipping Conditions
Ambient, Refrigerated
Shipping Recommendations
AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.
Specimen Rejection Criteria
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Test Details
Synonyms
SYT gene rearrangement, 18q11, 18q11.2 rearrangement
Keywords
Fluorescence in-situ Hybridization, Oncology, Oncology FISH Probes, Sarcoma
Test Method
Fluorescence in situ hybridization (FISH)
Methodology Category
FISH
Special Considerations
All attempts will be made to process and report samples received > 72 hours post-collection. Bone marrow is the sample of choice in most heme malignancies.
Associations
Synovial sarcomas