Myeloproliferative Disorders (MPD) Panel

Test ID: F MPD CPT Code: 88374 x4 (if automated read), 88377 (if manual read)

Expected Turnaround Time

5 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.

Clinical Information

FISH panel test on hematologic specimens for the most common abnormalities observed in myeloproliferative disorders. Includes: trisomy 8, BCR::ABL1 gene fusion, 13q deletion, and 20q deletion.

Requisition Forms

Oncology Pathology Requisition

Specimen Requirements

Whole Blood: 5 mL, EDTA preferred (NaHep accepted)
Bone Marrow Aspirate: 3 mL, EDTA preferred (NaHep accepted)

Specimen Stability

72 hours

Storage Requirements

Whole Blood: 2°C to 25°C
Bone Marrow Aspirate: 2°C to 25°C
Fixed Cytogenetically Prepared Cells: -28°C to -15°C

Shipping Conditions

Ambient, Refrigerated

Shipping Recommendations

AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.

Specimen Rejection Criteria

Clotted specimen; Specimens exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells

Test Details

Synonyms

+8. BCR/ABL t(9;22), 13q-, 20q-

Keywords

Fluorescence in-situ Hybridization, Leukemia, Myeloproliferative Disease (MPD), Oncology FISH Panels

Test Method

Fluorescence in situ hybridization (FISH)

Methodology Category

FISH

Regulatory Status

ASR

Special Considerations

All attempts will be made to process and report samples received > 72 hours post-collection. Bone marrow is the sample of choice in most heme malignancies.

Associations

Myeloproliferative disorder (MPD)