MM Reflex Panel – IGH/FGFR3 and IGH/MAF

Test ID: F MMREF CPT Code: 88374 x8 (if automated read), 88377 (if manual read)

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Expected Turnaround Time

5 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.

Clinical Information

FISH panel test on CD138+ cells in bone marrow specimens for IGH::FGFR3 fusion / t(4;14) and IGH::MAF fusion / t(14;16). Reflexed when gains of IGH are observed in the Plasma Cell Neoplasm Panel. Can be ordered as a stand-alone test.

Requisition Forms

Oncology Pathology Requisition

Specimen Requirements

Whole Blood: 5 mL, EDTA preferred (NaHep accepted)
Bone Marrow Aspirate: 3 mL, EDTA preferred (NaHep accepted)

Specimen Stability

72 hours

Storage Requirements

Whole Blood: 2°C to 25°C
Bone Marrow Aspirate: 2°C to 25°C
Fixed Cytogenetically Prepared Cells: -28°C to -15°C

Shipping Conditions

Ambient, Refrigerated

Shipping Recommendations

AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.

Specimen Rejection Criteria

Clotted specimen; Specimens exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells

Test Details

Synonyms

FGFR3/IGH, MAF/IGH, JTK4, MAF1

Keywords

Fluorescence in-situ Hybridization, Oncology, Myeloma, Oncology FISH Panels

Test Method

Fluorescence in situ hybridization (FISH)

Methodology Category

FISH

Regulatory Status

ASR

Special Considerations

All attempts will be made to process and report samples received > 72 hours post-collection. Bone marrow is the sample of choice in most heme malignancies.

Associations

Multiple Myeloma

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