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SYT 18q11.2 Synovial Sarcoma*, paraffin

Test ID: FP SYT* CPT Code: 88377
Expected Turnaround Time
9 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.
Clinical Information
FISH testing on paraffin-embedded cells for Synovial sarcomas, which account for 5-10% of soft tissue sarcomas, are seen mainly in adolescents and adults aged between 15 and 45 years. More than 85-95% of them arise in the deep soft tissues of the extremities. Synovial sarcomas harbor the t(X;18) translocation. *Testing performed by affiliate laboratory.

Specimen Requirements

Specimen Requirements
  • FFPE Tissue Block
  • Unstained FFPE tissue: 5 slides preferred (3 slides minimum) cut at 3-5 μM and mounted on positively charged slides. 
Specimen Stability

Stable indefinitely

Storage Requirements

15°C to 25°C

Shipping Conditions
Ambient
Shipping Recommendations

AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.

Specimen Rejection Criteria

Improper fixative; Tissue not fixed; Insufficient tissue; Specimen exposed to extreme temperature

Test Details

Synonyms

SYT gene rearrangement, 18q11, 18q11.2 rearrangement

Keywords
Fluorescence in-situ Hybridization, Oncology, Oncology FISH Probes, Sarcoma
Test Method
Fluorescence in situ hybridization (FISH) *Performed by affiliate laboratory
Methodology Category
FISH
Regulatory Status
ASR
Special Considerations

Tissues should be fixed in 10% neutral buffered formalin (NBF). Tissues preserved in B+ fixative or decalcified are usually not suitable for FISH. Assay requires 3 unstained slides minimum (two for each probe) and one H&E stained slide. If unstained slides are sent, cut FFPE tissue sections at 3-5 μm thickness, mounted on positively charged slides. 

Associations

Synovial sarcomas