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IGH/MYC t(8;14), paraffin

Test ID: FP IGH MYC CPT Code: 88377
Expected Turnaround Time
5 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.
Clinical Information
FISH testing on paraffin-embedded cells for detection of IGH::c-MYC gene fusion associated with t(8;14). Depending on clinical, immunophenotypic, and morphologic context, IGH::c-MYC fusion can support a diagnosis of Burkitt lymphoma. However, this fusion may occur in the progression of non-Burkitt lymphomas and plasma cell neoplasms. Often ordered as part of the FP BURKITT Panel test.

Specimen Requirements

Specimen Requirements
  • FFPE Tissue Block
  • Unstained FFPE tissue: 5 slides preferred (3 slides minimum) cut at 3-5 μM and mounted on positively charged slides. 
Specimen Stability

Stable indefinitely

Storage Requirements

15°C to 25°C

Shipping Conditions
Ambient
Shipping Recommendations

AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.

Specimen Rejection Criteria

Improper fixative; Tissue not fixed; Insufficient tissue; Specimen exposed to extreme temperature

Test Details

Synonyms

t(8;14)(q32;q24), MYC, BHLHE39

Keywords
Fluorescence in-situ Hybridization, Oncology, Oncology FISH Probes, Lymphoma
Test Method
Fluorescence in situ hybridization (FISH) *Performed by affiliate laboratory
Methodology Category
FISH
Regulatory Status
ASR
Special Considerations

Tissues should be fixed in 10% neutral buffered formalin (NBF). Tissues preserved in B+ fixative or decalcified are usually not suitable for FISH. Assay requires 3 unstained slides minimum (two for each probe) and one H&E stained slide. If unstained slides are sent, cut FFPE tissue sections at 3-5 μm thickness, mounted on positively charged slides. 

Associations

Burkitt lymphoma