IGH 14q32 Rearrangement*

Test ID: F IGH* CPT Code: 88374 (if automated read), 88377 (if manual read)

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Expected Turnaround Time

9 days
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract.

Clinical Information

FISH test on hematologic specimens for detection of IGH (14q32) gene rearrangement. IGH is frequently rearranged in a variety of neoplasms, including B-cell lymphoma, lymphoproliferative disorder, CLL, and myeloid neoplasms. *Testing performed by affiliate laboratory.

Specimen Requirements

Whole Blood: 5 mL, EDTA preferred (NaHep accepted)
Bone Marrow Aspirate: 3 mL, EDTA preferred (NaHep accepted)

Specimen Stability

72 hours

Storage Requirements

Whole Blood: 2°C to 25°C
Bone Marrow Aspirate: 2°C to 25°C
Fixed Cytogenetically Prepared Cells: -28°C to -15°C

Shipping Conditions

Ambient, Refrigerated

Shipping Recommendations

AMBIENT, Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Separate gel pack from specimen. Do not freeze.

Specimen Rejection Criteria

Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells

Test Details

Synonyms

Immunoglobulin heavy chain, 14q32 rearrangement, 14q32/IGH

Keywords

Fluorescence in-situ Hybridization, Oncology, Oncology FISH Probes, Lymphoma, Myeloma

Test Method

Fluorescence in situ hybridization (FISH) *Performed by affiliate laboratory

Methodology Category

FISH

Special Considerations

All attempts will be made to process and report samples received > 72 hours post-collection. Bone marrow is the sample of choice in most heme malignancies.

Associations

Non-Hodgkin lymphoma, Myeloma

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